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Pain Management
Pain Management
Chronic pain is a debilitating condition that is experienced by millions of Americans. The use of biologics to alleviate pain is an exciting field of medicine. Several Cervos products are used by cutting edge clinicians to address chronic pain in a creative, safe, and minimally invasive manner.
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Scientific Resources
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Technique Guide: Bone Marrow Aspirate from the Iliac Crest using the CER-ORTHOQuickly and efficiently aspirate high quality bone marrow with limited peripheral blood dilution using the 11 Guage CER-ORTHO device powered by patented Marrow Cellution™ technology.
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Technique Guide: Cervos 15 Gauge for Small Bone AccessTechnique Guide: Cervos 15 Gauge for Small Bone Access
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Research That Demonstrates That Higher Cell Counts Measured by CFU-f Have Better Outcomes
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Pettine et al Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months.Stem Cells 2015 Jan;33(1):146-56.This work documents that higher CFU-f relevies back pain due to disc herniation in a dose response
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Research That Demonstrates That Higher Cell Counts Measured by CFU-F Are Achieved by MC
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Bianco S et al Comparison of Two Methods to Harvest Vertebral Body Marrow Aspirate. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Vertebral body. It also shows MC is superior to Harvest
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Scarpone M et al Marrow Cellution: The Impact of Volume on Related Cell Counts Using The Marrow Cellution Bone Marrow Aspiration System. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac Crest.
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Tortland P et al Technique Matters: Small Draw, Diverse Geography, Precise Repositioning, Lateral Draws Only, Pace, and Syringe Plunger Yields Clinically Relevant CFU-f Counts. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac crest.
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Scarpone M et al Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine Vol. 17, No. 10 (2019)This work documents the CFU-f count of MC verses Harvest and Emcyte
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Beri M et al. Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction Journal of Translational Medicine vol. 18, No. 24, 2020This work documents the CFU-f count of MC verses Magelan
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Scient_014This power point summarizes all relevant published work comparing MC to Centrifuge Systems
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Hernigou et al Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cellsThis work demonstrates a small aspirate is superior; scientific validation for using MC
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Muschler et al Aspiration to Obtain Osteoblast Progenitor Cells from Human Bone Marrow: The Influence of Aspiration Volume*This work demonstrates a small aspirate uisng a 10cc syringe is superior; scientific validation for using MC
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McLain et al ASPIRATION OF OSTEOPROGENITOR CELLS FOR AUGMENTING SPINAL FUSION: COMPARISON OF PROGENITOR CELL CONCENTRATIONS FROM THE VERTEBRAL BODY AND ILIAC CRESTThis work demonstrates the CFU-f count using a traditional needle in the iliac crest and spine
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Muschler et al COMPARISON OF BONE MARROW ASPIRATION AND BONE CORE BIOPSY AS METHODS FOR HARVEST AND ASSAY OF HUMAN CONNECTIVE TISSUE PROGENITORThis work demonstrates how many CFU-f are contained in autograft
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Hegde V, et al A prospective comparison of 3 approved systems for autologous bone marrow concentration demonstrated nonequivalency in progenitor cell number and concentration. J Orthop Trauma. 2014;28(10):591–8.This work demostrates the number of CFU-f obtained after centrifugation for Harvest, Magellen, and Biomet
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Harrell D et al Novel Technology to Increase the Concentrations of Stem and Progenitor Cells in a Marrow Aspirate. White PapeerEarly white papers documenting CFU-f counts for MC
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Scarpone M et al Marrow Ceelution Bone Marrow Aspiration System and Related Concentratins of Stem and Progenitor Cells. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTION™ AND EMCYTE® BMC SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTIONTM AND THE BMAC® HARVEST®/TERUMO® SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Research That Demonstrates That MC Has a Positive Clinical Effect
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Beri M et al. Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction Journal of Translational Medicine vol. 18, No. 24, 2020This paper documents the use of MC in Erectile Dysfunction compared to a Centrifuge System
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Scient_025This paper documents the benefit of using Marrow, adipose tissue and PRP for advanced knee osteoarthritis
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Colberg R et al Short-term outcomes after pure bone marrow aspirate injection for severe knee osteoarthritis: a case seriesRegenerative Medicine Published online:4 September 2020This paper demonstrates the benefit of using Marrow alone for advanced knee OA
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Varadt H et al. Positive early clinical outcomes of bone marrow aspirate concentrate or osteoarthritis using a novel fenestrated trocarThe Knee, volume 27, Issue 5, October 2020, Pages 1627-1634This paper demonstrates the benefit of using Marrow alone for advanced knee OA
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Henderson RG, Colberg RE. Pure bone marrow aspirate injection for chronic greater trochanteric pain syndrome: a case report. Pain Manag. 8(4), 271–275 (2018).This paper demonstrates the benefit of using Marrrow to treat Trochanter hip pain
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Research That Summarizes the Key Aspects of Cellular Biology As It Relates to Tissue Healing
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Scient_031This blog summarizes how vasculogenesis is the cornerstone of tissue regeneration
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Scient_032This blog summarizes the importance of minimzing manipulative steps to biologics in a post COVID world
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Scient_033This white paper summarizes the general science at a cellular level for tissue regeneration
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Scient_034Thiswhite paper discusses the rlationship between different cell markers
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