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Ortho Spine
Ortho Spine
A critical question in any spine fusion case is “Will I get a graft failure before I get fusion?” Using the correct biologic and graft material can make all the difference in making sure the answer to that question is “I got a fusion”. The Cervos Ortho Spine line was developed based on our deep knowledge of bone formation and bone marrow.
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Scientific Resources
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Technique Guide: Bone Marrow Aspirate from the Iliac Crest using the CER-ORTHOQuickly and efficiently aspirate high quality bone marrow with limited peripheral blood dilution using the 11 Guage CER-ORTHO device powered by patented Marrow Cellution™ technology.
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Technique Guide: Extracting a bone dowel with the 11 gauge CER-BN-116 over the 8 gauge CER-SUB-83NWith the CER-SUB-83N device acting as a port, the proprietary CER-BN-116 dowel extraction device avoids cortical bone friction allowing for increased ease of use in capturing bone dowels from the iliac crest.
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Technique Guide: Extracting a bone dowel from the Iliac Crest using the CER-BN-116The proprietary CER-BN-116 bone dowel extraction system allow for minimally invasive harvesting of cancellous bone. This technique is most commonly used in procedures where a small volume of cancellous bone graft is desired.
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Technique Video: Bone Marrow Aspiration - Posterior Iliac CrestTechnique Video: Bone Marrow Aspiration - Posterior Iliac Crest
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Technique Video: Bone Dowel Harvesting - Posterior Iliac CrestTechnique Video: Bone Dowel Harvesting - Posterior Iliac Crest
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Research That Demonstrates That Higher Cell Counts Measured by CFU-f Have Better Outcomes
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Gan Y et al The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion Biomaterials, 2008, 3973-3982This work documented that grafts that contain CFU-f greater than 800 CFU-f / mL had reliabe lumbar fusions of greater than 90% using TCP as the functional matrix
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Yamada T et al. Hybrid grafting using bone marrow aspirate combined with porous β-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion: a prospective, comparative study versus local bone grafting.combination of marrow aspirate, trephine assisted dowel graft and TCP graft material had the same fusion rate as autograft in the gutter of the lumbar spine without the associated morbidity.
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Research That Demonstrates That Higher Cell Counts Measured by CFU-F Are Achieved by MC
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Bianco S et al Comparison of Two Methods to Harvest Vertebral Body Marrow Aspirate. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Vertebral body. It also shows MC is superior to Harvest
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Scarpone M et al Marrow Cellution: The Impact of Volume on Related Cell Counts Using The Marrow Cellution Bone Marrow Aspiration System. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac Crest.
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Tortland P et al Technique Matters: Small Draw, Diverse Geography, Precise Repositioning, Lateral Draws Only, Pace, and Syringe Plunger Yields Clinically Relevant CFU-f Counts. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac crest.
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Scarpone M et al Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine Vol. 17, No. 10 (2019)This work documents the CFU-f count of MC verses Harvest and Emcyte
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Beri M et al. Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction Journal of Translational Medicine vol. 18, No. 24, 2020This work documents the CFU-f count of MC verses Magelan
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Scient_014This power point summarizes all relevant published work comparing MC to Centrifuge Systems
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Hernigou et al Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cellsThis work demonstrates a small aspirate is superior; scientific validation for using MC
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Muschler et al Aspiration to Obtain Osteoblast Progenitor Cells from Human Bone Marrow: The Influence of Aspiration Volume*This work demonstrates a small aspirate uisng a 10cc syringe is superior; scientific validation for using MC
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McLain et al ASPIRATION OF OSTEOPROGENITOR CELLS FOR AUGMENTING SPINAL FUSION: COMPARISON OF PROGENITOR CELL CONCENTRATIONS FROM THE VERTEBRAL BODY AND ILIAC CRESTThis work demonstrates the CFU-f count using a traditional needle in the iliac crest and spine
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Muschler et al COMPARISON OF BONE MARROW ASPIRATION AND BONE CORE BIOPSY AS METHODS FOR HARVEST AND ASSAY OF HUMAN CONNECTIVE TISSUE PROGENITORThis work demonstrates how many CFU-f are contained in autograft
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Hegde V, et al A prospective comparison of 3 approved systems for autologous bone marrow concentration demonstrated nonequivalency in progenitor cell number and concentration. J Orthop Trauma. 2014;28(10):591–8.This work demostrates the number of CFU-f obtained after centrifugation for Harvest, Magellen, and Biomet
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Harrell D et al Novel Technology to Increase the Concentrations of Stem and Progenitor Cells in a Marrow Aspirate. White PapeerEarly white papers documenting CFU-f counts for MC
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Scarpone M et al Marrow Ceelution Bone Marrow Aspiration System and Related Concentratins of Stem and Progenitor Cells. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTION™ AND EMCYTE® BMC SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTIONTM AND THE BMAC® HARVEST®/TERUMO® SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Research That Summarizes the Key Aspects of Cellular Biology As It Relates to Tissue Healing
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Scient_030This web page generally discusses the importance of adding a small amount of autogenous bone to the graft
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Scient_031This blog summarizes how vasculogenesis is the cornerstone of tissue regeneration
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Scient_032This blog summarizes the importance of minimzing manipulative steps to biologics in a post COVID world
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Scient_033This white paper summarizes the general science at a cellular level for tissue regeneration
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Scient_034Thiswhite paper discusses the rlationship between different cell markers
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Scient_035This paper documents the science behind using MC aspirate with a functioning matrix
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