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Intradiscal
Back pain that is caused by disc herniation or deterioration impacts the lives of millions of people. Access to the disc and the ability to treat damage is a challenging problem due to the disc’s location, shape, and structure. Several Cervos products are used by cutting edge clinicians to address chronic disc pain in a creative, safe, and minimally invasive manner.
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Scientific Resources
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Technique Guide: Bone Marrow Aspirate from the Iliac Crest using the CER-ORTHOQuickly and efficiently aspirate high quality bone marrow with limited peripheral blood dilution using the 11 Guage CER-ORTHO device powered by patented Marrow Cellution™ technology.
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Research That Demonstrates That Higher Cell Counts Measured by CFU-f Have Better Outcomes
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Pettine et al Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months.Stem Cells 2015 Jan;33(1):146-56.This work documents that higher CFU-f relevies back pain due to disc herniation in a dose response
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Research That Demonstrates That Higher Cell Counts Measured by CFU-F Are Achieved by MC
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Bianco S et al Comparison of Two Methods to Harvest Vertebral Body Marrow Aspirate. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Vertebral body. It also shows MC is superior to Harvest
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Scarpone M et al Marrow Cellution: The Impact of Volume on Related Cell Counts Using The Marrow Cellution Bone Marrow Aspiration System. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac Crest.
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Tortland P et al Technique Matters: Small Draw, Diverse Geography, Precise Repositioning, Lateral Draws Only, Pace, and Syringe Plunger Yields Clinically Relevant CFU-f Counts. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac crest.
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Scarpone M et al Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine Vol. 17, No. 10 (2019)This work documents the CFU-f count of MC verses Harvest and Emcyte
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Beri M et al. Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction Journal of Translational Medicine vol. 18, No. 24, 2020This work documents the CFU-f count of MC verses Magelan
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Scient_014This power point summarizes all relevant published work comparing MC to Centrifuge Systems
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Hernigou et al Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cellsThis work demonstrates a small aspirate is superior; scientific validation for using MC
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Muschler et al Aspiration to Obtain Osteoblast Progenitor Cells from Human Bone Marrow: The Influence of Aspiration Volume*This work demonstrates a small aspirate uisng a 10cc syringe is superior; scientific validation for using MC
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McLain et al ASPIRATION OF OSTEOPROGENITOR CELLS FOR AUGMENTING SPINAL FUSION: COMPARISON OF PROGENITOR CELL CONCENTRATIONS FROM THE VERTEBRAL BODY AND ILIAC CRESTThis work demonstrates the CFU-f count using a traditional needle in the iliac crest and spine
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Muschler et al COMPARISON OF BONE MARROW ASPIRATION AND BONE CORE BIOPSY AS METHODS FOR HARVEST AND ASSAY OF HUMAN CONNECTIVE TISSUE PROGENITORThis work demonstrates how many CFU-f are contained in autograft
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Hegde V, et al A prospective comparison of 3 approved systems for autologous bone marrow concentration demonstrated nonequivalency in progenitor cell number and concentration. J Orthop Trauma. 2014;28(10):591–8.This work demostrates the number of CFU-f obtained after centrifugation for Harvest, Magellen, and Biomet
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Harrell D et al Novel Technology to Increase the Concentrations of Stem and Progenitor Cells in a Marrow Aspirate. White PapeerEarly white papers documenting CFU-f counts for MC
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Scarpone M et al Marrow Ceelution Bone Marrow Aspiration System and Related Concentratins of Stem and Progenitor Cells. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTION™ AND EMCYTE® BMC SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTIONTM AND THE BMAC® HARVEST®/TERUMO® SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Research That Summarizes the Key Aspects of Cellular Biology As It Relates to Tissue Healing
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Scient_031This blog summarizes how vasculogenesis is the cornerstone of tissue regeneration
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Scient_032This blog summarizes the importance of minimzing manipulative steps to biologics in a post COVID world
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Scient_033This white paper summarizes the general science at a cellular level for tissue regeneration
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Scient_034Thiswhite paper discusses the rlationship between different cell markers
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