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Extremity
Extremity
Orthopedic maladies in the extremity of the skeleton, including the major joints of the foot and ankle, wrist and hand, elbow, and shoulder often require surgical instruments that are specifically designed to make access and treatment less invasive and more efficient. The Cervos Extremity line of products has been designed to meet the challenging clinical environment surgeons encounter in the extremities of the skeleton.
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Scientific Resources
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Case Study: Percutaneous Bone Grafting In An Outpatient SettingSuccessful Bridging and Repair of First Metatarsal Fracture with Chronic Pseudoarthrosis Following Multiple Surgical Interventions Using a Minimally Invasive Approach
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Technique Guide: Extracting a bone dowel from the proximal tibia using the CER-BN-84The proprietary CER-BN-84 bone dowel extraction system allows for minimally invasive harvesting of cancellous bone. This technique is most commonly used in foot and ankle procedures where iliac crest harvesting is undesirable.
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Technique Guide: Extracting a bone dowel from the Iliac Crest using the CER-BN-116The proprietary CER-BN-116 bone dowel extraction system allow for minimally invasive harvesting of cancellous bone. This technique is most commonly used in procedures where a small volume of cancellous bone graft is desired.
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Technique Guide: Minimally invasive core decompression and biological repair of subchondral lesionsA novel technique for minimally invasive joint preservation surgery using a family of Cervos products, this technique guide demonstrates how to target and repair bone marrow lesions utilizing a variety of Cervos devices & biologics.
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Technique Guide: Cervos 15 Gauge for Small Bone AccessTechnique Guide: Cervos 15 Gauge for Small Bone Access
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Technique Video: Bone Dowel Harvesting - Posterior Iliac CrestTechnique Video: Bone Dowel Harvesting - Posterior Iliac Crest
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Technique Video: Subchondral Repair - Proximal TibiaTechnique Video: Subchondral Repair - Proximal Tibia
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Technique Video: Bone Dowel Harvesting - Proximal TibiaTechnique Video: Bone Dowel Harvesting - Proximal Tibia
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Technique Video: Non Union Repair - Distal TibiaTechnique Video: Non Union Repair - Distal Tibia
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Technique Video: Bone Marrow Aspiration - Distal TibiaTechnique Video: Bone Marrow Aspiration - Distal Tibia
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Technique Video: Bone Dowel Harvesting - Anterior Iliac CrestTechnique Video: Bone Dowel Harvesting - Anterior Iliac Crest
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Technique Video: Bone Marrow Aspiration - Anterior Iliac CrestTechnique Video: Bone Marrow Aspiration - Anterior Iliac Crest
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Research That Demonstrates That Higher Cell Counts Measured by CFU-f Have Better Outcomes
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Hernigou et al Percutaneous Autologous Bone-Marrow Grafting for Non-UnionsThis work demonstrates that you need at least 1500 CFU-f per mL to treat a non union through percutaneous injection of marrow aspirate. Non Unions that had below this minimal dose were failures. Only CFU-f per mL of the aspriate rose to statistical significance.
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Hernigou et al Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled studyThis work demonstrates a positive dose response for CFU-f per mL to augment treatment of osteonecrosis of the hip using core decompression. Grafts that had a significantly higher failure rate had lower CFU-f per mL in the graft.
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Henigou and Beaujean Treatment of Osteonecrosis with Autologous Bone Marrow GraftingThis work documented that grafts that higher CFU-f concentrations had a better effect for osteonecrosis of the hip when combined with core decompression
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Gangji et al Treatment of Osteonecrosis of the Femoral Head with Implantation of Autologous Bone-Marrow CellsThis work demonstrates that use of marrow stem cells injected into the femoral head during core decomprssion imporved outcomes comapred to decompresssion alone.
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Research That Demonstrates That Higher Cell Counts Measured by CFU-F Are Achieved by MC
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Bianco S et al Comparison of Two Methods to Harvest Vertebral Body Marrow Aspirate. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Vertebral body. It also shows MC is superior to Harvest
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Scarpone M et al Marrow Cellution: The Impact of Volume on Related Cell Counts Using The Marrow Cellution Bone Marrow Aspiration System. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac Crest.
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Tortland P et al Technique Matters: Small Draw, Diverse Geography, Precise Repositioning, Lateral Draws Only, Pace, and Syringe Plunger Yields Clinically Relevant CFU-f Counts. White PaperThis work documents the CFU-f count of MC equals Autograft when drawing from the Iliac crest.
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Scarpone M et al Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine Vol. 17, No. 10 (2019)This work documents the CFU-f count of MC verses Harvest and Emcyte
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Beri M et al. Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction Journal of Translational Medicine vol. 18, No. 24, 2020This work documents the CFU-f count of MC verses Magelan
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Scient_014This power point summarizes all relevant published work comparing MC to Centrifuge Systems
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Hernigou et al Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cellsThis work demonstrates a small aspirate is superior; scientific validation for using MC
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Muschler et al Aspiration to Obtain Osteoblast Progenitor Cells from Human Bone Marrow: The Influence of Aspiration Volume*This work demonstrates a small aspirate uisng a 10cc syringe is superior; scientific validation for using MC
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McLain et al ASPIRATION OF OSTEOPROGENITOR CELLS FOR AUGMENTING SPINAL FUSION: COMPARISON OF PROGENITOR CELL CONCENTRATIONS FROM THE VERTEBRAL BODY AND ILIAC CRESTThis work demonstrates the CFU-f count using a traditional needle in the iliac crest and spine
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Muschler et al COMPARISON OF BONE MARROW ASPIRATION AND BONE CORE BIOPSY AS METHODS FOR HARVEST AND ASSAY OF HUMAN CONNECTIVE TISSUE PROGENITORThis work demonstrates how many CFU-f are contained in autograft
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Hegde V, et al A prospective comparison of 3 approved systems for autologous bone marrow concentration demonstrated nonequivalency in progenitor cell number and concentration. J Orthop Trauma. 2014;28(10):591–8.This work demostrates the number of CFU-f obtained after centrifugation for Harvest, Magellen, and Biomet
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Harrell D et al Novel Technology to Increase the Concentrations of Stem and Progenitor Cells in a Marrow Aspirate. White PapeerEarly white papers documenting CFU-f counts for MC
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Scarpone M et al Marrow Ceelution Bone Marrow Aspiration System and Related Concentratins of Stem and Progenitor Cells. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTION™ AND EMCYTE® BMC SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Scarpone M et al COMPARATIVE ANALYSIS OF MARROW CELLUTIONTM AND THE BMAC® HARVEST®/TERUMO® SYSTEM. White PaperEarly white papers documenting CFU-f counts for MC
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Research That Demonstrates That MC Has a Positive Clinical Effect
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Scient_025This paper documents the benefit of using Marrow, adipose tissue and PRP for advanced knee osteoarthritis
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Colberg R et al Short-term outcomes after pure bone marrow aspirate injection for severe knee osteoarthritis: a case seriesRegenerative Medicine Published online:4 September 2020This paper demonstrates the benefit of using Marrow alone for advanced knee OA
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Research That Summarizes the Key Aspects of Cellular Biology As It Relates to Tissue Healing
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Scient_030This web page generally discusses the importance of adding a small amount of autogenous bone to the graft
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Scient_031This blog summarizes how vasculogenesis is the cornerstone of tissue regeneration
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Scient_032This blog summarizes the importance of minimzing manipulative steps to biologics in a post COVID world
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Scient_033This white paper summarizes the general science at a cellular level for tissue regeneration
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Scient_034Thiswhite paper discusses the rlationship between different cell markers
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Scient_035This paper documents the science behind using MC aspirate with a functioning matrix
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Research That Summarizes the Importance of Treating Sub Chondral Bone Edema
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Camp C et al Spontaneous Osteonecrosis/Subchondral Insufficiency Fractures of the Knee High Rates of Conversion to Surgical Treatment and ArthroplastyThe Journal of Bone and Joint Surgery: May 6, 2020 - Volume 102 - Issue 9 - p 821-829This paper discusses how sub chondral knee edema is correlated with knee replacement surgery
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Kasik S. et al Short-Term Outcomes for the Biologic Treatment of Bone Marrow Edema of the Knee Using Bone Marrow Aspirate Concentrate and Injectable Demineralized Bone Matrix Arthroscopy, Sports Medicine and Rehabilitation. Volume 1 Issue 1 November 2019.This paper discusses how sub chondral knee edema can be treated effectively with marrow aspirate
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Muratovic D et al Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration Osteoarthritis and Cartilage Volume 27, Issue 11, November 2019. pg 1653-1662.This paper discusses how sub chondral knee edema is correlated with knee replacement surgery
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